Dharmik Desai, PharmD
Senior Director, Medical Affairs
Leading the Way in Complement Science
At Apellis, we are dedicated to leading the way in complement science for nephrology. We believe that targeting the complement protein C3 may hold broader potential across a range of serious kidney diseases and conditions.
The Complement System
A central component of the innate immune system that, upon activation, initiates a signaling cascade to eliminate foreign or damaged cells. Many diseases/conditions are mediated by complement dysregulation, and complement activation can occur at multiple points during the kidney transplantation process.
Complement Overactivation Underlies the Rare Kidney Diseases C3G and Primary IC‑MPGN
C3G and primary IC‑MPGN are rare, progressive glomerular diseases caused by complement system overactivation. Up to 50% of patients with C3G or primary IC‑MPGN progress to ESKD in 5-10 years.
Transplantation Is Not a Cure for Patients With C3G or Primary IC‑MPGN
Because transplantation does not target the underlying complement overactivation that causes C3G and primary IC‑MPGN, up to 89% of patients experience disease recurrence post transplant. Allograft loss occurs in up to 60% of posttransplant patients.
The Complement System
The complement system is a central component of the innate immune system that, upon activation, initiates a signaling cascade to eliminate foreign or damaged cells. Many diseases/conditions are mediated by complement dysregulation, and complement activation can occur at multiple points during the kidney transplantation process.
Watch the video to learn more.
Complement Overactivation Underlies the Rare Kidney Diseases C3G and Primary IC‑MPGN
What Are C3G and Primary IC‑MPGN?: An Overview From Jai Radhakrishnan, MD
Key information includes:- Prevalence
- Underlying cause
- Common signs and symptoms
- Diagnosis and prognosis
The Complement System and Its Role in C3G and Primary IC‑MPGN: An Overview From Dr. Laura Mariani
Key information includes:- The role of the complement system
- Common drivers of disease
- Physiological consequences of complement overactivation
Presentation and Diagnosis of C3G and Primary IC‑MPGN: A Conversation With Dr. Anthony Chang and Dr. Suneel Udani
Learn about the hallmarks of C3G and primary IC‑MPGN and how these diseases are diagnosed
Kidney Transplantation Is Not the End of the Road for Patients With C3G or Primary IC‑MPGN
Mary’s Story of Living With C3G
Key information includes:- Disease presentation and diagnosis
- Evolution of treatment with disease progression
- Transplant journey
Management of C3G and Primary IC‑MPGN: A Case-Based Discussion With Dr. Jai Radhakrishnan and Dr. Mariela Navarro-Torres
Key information includes:- Patient’s diagnostic journey
- Treatment options and patient management
- The integral role of biopsy
- Transplantation and disease recurrence
What can I expect to see in lab results of patients with C3G or primary IC‑MPGN?
Learn about some of the common complement biomarkers associated with C3G and primary IC‑MPGN and what these lab results could mean.